SOX2 and glioblastoma: Interestingly, recent data concerning biomolecular characteristics of GS documented that, although GS has a genetic profile that overlaps with GBM and other neoplasms, it is also true that GS has its genetic mutations, such as MSH6, BRAF, SUZ12, SOX2, and FBXW7 [2,3,10,11,16,80].