TNF and rheumatoid arthritis: Abatacept is approved for the treatment of adult patients with highly active, progressive rheumatoid arthritis (RA) not previously treated with methotrexate, and for the treatment of active rheumatoid arthritis (moderate-to-severe) in adult patients who show an inadequate response to previous treatment or intolerance to current treatment with one or more disease-modifying antirheumatic drugs or inhibitors of tumor necrosis factor (anti-TNF) [96].