Via univariate Cox regression analysis, we identified several factors that were associated with renal progression in primary MN patients, including age, urine protein, eGFR, hypertension, diabetes, use of immunosuppressive therapy, tubulo-interstitial lesions ≥ 25%, SAb+/GAg−, and SAb+/GAg+. The gene discussed is SH3BP5; the disease is diabetes mellitus.