As to the effect of gender on the response to abatacept, this was studied in the French Orencia and Rheumatoid arthritis registry but failed to detect any difference in response or remission rates, or even time to achieve them, between men and women after adjustment by age, disease duration, seropositivity, current DMARDs, previous anti-TNF, corticoid use, and disease activity, although the DAS28-ESR, TJC, and PtGA remained higher in women [69]. Here, TNF is linked to rheumatoid arthritis.