ADORA1 and acute kidney injury: In the PROTECT (Placebo-Controlled Randomized Study of the Selective Adenosine A1 Receptor Antagonist Rolofylline for Patients Hospitalized with Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function) study, the rapid increase in the hemoglobin concentration during the first 7 days of hospitalization in patients presenting with acute decompensated heart failure was associated with a favorable outcome, despite the incidences of acute kidney injury (AKI) that were observed [48].