TIMP2 and acute kidney injury: Lacquaniti et al. evaluated the role of proadrenomedullin (a urine tissue inhibitor of metalloproteinase 2 insulin-like growth-factor-binding protein 7 (TIMP2 IGFBP7)) and mid-region proadrenomedullin (MR-proADM) in predicting AKI in patients with sepsis after cardiac surgery [21].