In colorectal cancer, resveratrol decreased the expression levels of characterized oncomiRs, as miR-17, miR-21, miR-25, and miR-92a-2 [102], and exerted a pivotal regulation on many tumor suppressors, such as PTEN and SMAD3, as well as on the oncogenic TGF-β pathway related to progression and metastasis of colorectal cancer by targeting the expression levels of miR-1 and miR-146b-5p [103]. The gene discussed is SMAD3; the disease is colorectal cancer.