The expression of miR-148a is downregulated in colorectal cancer (CRC), where it exerts a tumor-suppressor activity interfering in NF-κB and signal transducer and activator of transcription 3 (STAT3) pathways and modulating cancer related immune response via inhibition of the programmed death ligand-1 (PD-L1) levels [45]. The gene discussed is STAT3; the disease is colorectal cancer.