TP53 and cancer: Another significant milk-derived miRNA, miR-125b, increases the development of prostate xenograft cancer targeting proapoptotic genes, as p53, p53-upregulated modulator of apoptosis (PUMA), and BCL2 Antagonist/Killer 1 (BAK1) [48], and regulates several tumorigenic pathways, including NF-κB, p53, phosphatidyl inositol 3-kinase (PI3K)/protein kinase B (AKT)/mTORC1, erb-b2 receptor tyrosine kinase 2 (ERBB2), and Wnt [45].