With regard to the functioning of Mn-SOD, including its involvement in neutralizing free radicals as well as the pathway by which this enzyme is activated, which is under the influence of elevated levels of tumor-necrosis factor-alpha (TNF-α), the factor contributing to the maintenance of the inflammatory state in endometriosis, the association between Mn and endometriosis occurs [126]. Here, SOD2 is linked to endometriosis.