In addition, crocin can inhibit tumor invasion and metastasis through down-regulation of matrix metalloproteinase 2 and 9 (MMP2 and MMP9), N-cadherin, and beta-catenin expression and cell cycle suppression at G1, G0/G1, S, and G2/M phases [31]. The gene discussed is CTNNB1; the disease is neoplasm.