In silico RNA sequencing of prostate adenocarcinoma (PRAD) TCGA analysis demonstrated upregulation of DNMT3B, DNMT1, and MBD2 in tumors (n = 497) compared to normal (n = 52) samples (Figure 4A–C), suggesting a global increase in DNA methylation, which might be associated with gene-specific downregulation [21,22]. This evidence concerns the gene DNMT3B and prostate adenocarcinoma.