The offspring of mothers administered liraglutide or with dietary change in the perinatal period had significantly lowered serum insulin and HOMA-IR scores when compared to the offspring of mothers with obesity (serum insulin: H vs. HL, H vs. HPC, p < 0.01, H vs. HC, p < 0.001, HOMA-IR: H vs. HL, p < 0.01, H vs. HC, p < 0.0001, H vs. HPC, p < 0.001, Table 2). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.