NLRP3 and Parkinson disease: Furthermore, cordycepin protected dopaminergic neurons from death and inflammation by inhibiting dynamin-related protein-1 (Drp-1)-mediated (NOD)-like receptor protein 3 (NLRP3) inflammasome activation by increasing AMP-activated protein kinase (AMPK) phosphorylation in a rotenone-induced PD rat model and cultured PC12 cells [147].