SIRT1 and Alzheimer disease: The downregulated expression of AD-related genes presenilin 1 (PSEN1), presenilin 2 (PSEN2), and APP and the increased expression of the non-amyloidogenic pathway, ADAM metallopeptidase domain 10 (ADAM10), and sirtuin1 (SIRT1) by nanoencapsulated C. militaris extract suggest its potential in improving AD pathology at both the gene and protein levels [85].