INS and hydrops fetalis: In the male offspring, the glycemia AUC during the ipITT decreased from PD21 to PD28 and increased from PD28 to PD60 in both the NC and HF descendants (AUC glycemia during ipITT: NC PD21 = 807.8 ± 66.4; NC PD28 = 677.6 ± 23.9, p < 0.01; NC PD60 = 862.6 ± 19.5, p < 0.05; HF PD21 = 1022.2 ± 81.6; HF PD28 = 663.9 ± 41.2, p < 0.01; HF PD60 = 878.6 ± 34.9, p < 0.05) (Figure 2D, right panel), showing a significant increase in insulin sensitivity from PD21 to PD28 and a significant decrease in insulin sensitivity from PD28 to PD60 independent of maternal diet.