NPY and Anxiety: Moreover, since hypothalamic neurotransmitters like POMC and NPY are critical for energy balance and feeding [48] (it was found that a POMC-originated circuit regulates stress [49], the ablation of POMC neurons led to anxiety-like behavior [50], and NPY knockouts are related to anxiety [51]), other neurotransmitters will probably be keys in driving this stress/anxiety phenotype in the offspring of dysmetabolic mothers.