TNF and Cirrhosis: In a study of 77 patients, including 14 healthy controls, 14 patients with compensated cirrhosis and 49 patients with decompensated cirrhosis, Dirchwolf et al. found that compared to the healthy controls, the patients with cirrhosis had higher levels of multiple inflammatory cytokines including IL-6, IL-7, IL-8, IL-12 and TNF-α, with IL-6 and IL-8 levels correlating with MELD score [64].