Co-consumption of carbohydrate can support potassium uptake into cells through insulin-stimulating mechanisms to shift potassium intracellularly through ATPase channels, net base-producing fruits and vegetables decrease metabolic acidosis and the subsequent shift of potassium extracellularly to buffer the increase in hydrogen ion concentration, and fibre promotes reduced transit time and higher colonic excretion of potassium [15,48,49]. The gene discussed is INS; the disease is metabolic acidosis.