IL1B and idiopathic pulmonary fibrosis: After exposing normal and IPF-derived lung fibroblasts to a conditioned medium (CM) for 24 h, a notable increase in the expression of pro-inflammatory molecules IL-1β, TNF-α, Gal-3, and TGF-β was observed—as shown in Figure 6, no difference was found in the response to the CM in lung fibroblasts isolated from IPF patients when compared to those from control donors.