Our study demonstrated that when Hylach, a lactose-modified HA able to bind to Gal-3, was administered to TGF-β-stimulated fibroblasts derived from IPF subjects and controls, the expression of ECM components—collagen I, collagen III, elastin, and fibronectin—was dramatically reduced. This evidence concerns the gene TGFB1 and idiopathic pulmonary fibrosis.