Our study demonstrated that when Hylach, a lactose-modified HA able to bind to Gal-3, was administered to TGF-β-stimulated fibroblasts derived from IPF subjects and controls, the expression of ECM components—collagen I, collagen III, elastin, and fibronectin—was dramatically reduced. Here, LGALS3 is linked to idiopathic pulmonary fibrosis.