With the present study, we found that when the Gal-3 binding molecules Hylach were administered to the control and IPF human fibroblasts who had earlier been exposed to the CM of activated U937 monocyte, the expressions of the pro-inflammatory cytokines IL-1β, TNF-alpha, TGF-β and Gal-3 were strongly reduced. This evidence concerns the gene TNF and idiopathic pulmonary fibrosis.