Various studies have reported MALAT-1 overexpression in numerous cancers such as esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), non-small cell lung cancer (NSCLC), colorectal cancer (CRC), pancreatic cancer, breast cancer (BC), and hepatocellular carcinoma (HCC) [14,15,16,17,18,19,20,21,22,23,24]. This evidence concerns the gene MALAT1 and esophageal squamous cell carcinoma.