Although both cachexia and sarcopenia are also linked to elevated levels of CRP and IL-6 [19], these results may more likely be explained considering that elevated levels of CRP, LDH, and IL-6 seem to be associated with poor survival in different studies and with diminishing the effect of ICI due to their ability to modulate antitumor immune responses [44,45]. The gene discussed is CRP; the disease is Cachexia.