In colorectal cancer, SerpinB3, COX-2 and β-catenin have been found to be associated with more advanced tumor stages, and in vitro experiments have also shown that SerpinB3 determines the upregulation of COX-2/ β-catenin positive loops, which is associated with invasive histologic features [44]. The gene discussed is SERPINB3; the disease is colorectal cancer.