Moreover, in different cohorts of resected patients, the presence of genetic alterations of TP53 (tumor protein P53) and KRAS (Kirsten ras oncogene homolog) have been associated with a worse prognosis, characterized by a shorter OS and higher tumor recurrence, compared with in patients carrying isocitrate dehydrogenase (IDH)-1 and -2 mutations [14,21]. Here, TP53 is linked to neoplasm.