The detection of a PRKD1 p.Glu710Asp hotspot mutation or the translocation of one of the PRKD1, PRKD2, or PRKD3 genes is now considered highly specific for the diagnosis of PAC, as these molecular alterations are rarely detected in other salivary gland tumours. The gene discussed is PRKD3; the disease is tumor of salivary gland.