GO analysis of the genes upregulated in the symptomatic BPH group while downregulated in men with BPH/PCa revealed that SP140, a transcription factor that has been linked to control the expression of immune-related genes regulated by NF-κB emerged as the top transcription factor associated genes activated in BPH (Figure 3C). The gene discussed is NFKB1; the disease is benign prostatic hyperplasia.