Furthermore, the median values of basal (32.5 pg/mL, range 26–52) and stimulated serum CT (177 pg/mL, range 146–250) found in the group of patients with high FNA-CT and diffuse CCH were higher than the basal (17 pg/mL, range 15–31) and stimulated serum CT (40 pg/mL, range 35–210) observed in the group of patients with normal FNA-CT and absent or focal CCH. This evidence concerns the gene CALCA and columnar cell hyperplasia of the breast.