In the multivariable analysis (Table 5), the following variables were identified as independent risk factors for disease-specific survival; age at diagnosis (HR 1.04; 95%CI: 1.0–1.1; p < 0.001), WHO grading (in pairwise comparison with G1 as reference, the only significant (p < 0.001) difference was between G1 and NEC (Table 5 and Figure 2D) and p-CgA (HR per 2 fold increase 1.2; 95%CI: 1.2–1.3; p < 0.001). The gene discussed is CGA; the disease is neuroendocrine carcinoma.