CIITA and neoplasm: Syngeneic C57Bl/6 mice injected with GL261-CIITA intracerebrally did not develop any intracerebral tumor after 3 weeks, while the injection of GL261 cells transfected with an empty vector (pcDNA 3.1 plasmid, GL261-WT) resulted in large intracerebral tumors (87.95 mm3 [SD 17.75] vs. 0 mm3, p < 0.0001, Figure 1a–c).