On day 14, histological analysis showed that three-fourths of PBS-primed mice had developed large brain tumors (mean diameter 2585.25 μm [SD 2723.7]), while only one-sixth of the GL261-WT and one-fourth of the GL261-CIITA-primed mice developed a tumor (mean diameter 158.67 μm [SD 388.7] and mean diameter 39.8 μm [SD 79.5]; one-way ANOVA p = 0.045, Figure 2b,c). This evidence concerns the gene CIITA and brain neoplasm.