The clinical data sheet suggested that high ESM1 expression was closely related to vascular invasion (Table S2), so we detected the expression of angiogenesis targets (CD31 and VEGFA) in adjacent and GC tissues by Western blot, and the results showed that CD31 and VEGFA expression was higher in gastric cancer tissues than in adjacent tissues (Figure S1F,G). This evidence concerns the gene VEGFA and gastric cancer.