Rather, metronomic chemotherapy may address the weaknesses of pulsed chemotherapies, targeted therapies, oncogene-directed, or non-oncogene ‘addicted’ therapies by targeting the tumor’s plasticity via phenotypic editing of undruggable genetic defects in tumor cells, for example, in AML patients with complex chromosomal aberrations, including defects in gatekeeper genes such as TP53 mutations and PTEN downregulation, which may be counteracted with pioglitazone [13,45,100]. This evidence concerns the gene PTEN and neoplasm.