In this study, we aimed to investigate the expression status of NRAS, FGF-1, NGF, and KDR in non-metastatic CRC patients and metastatic ones, as well as in primary CRC and paired samples of the liver metastatic lesions of patients, which may help to support the definition of specific molecular characteristics or biomarkers of metastases. This evidence concerns the gene NGF and colorectal carcinoma.