In the meta-analysis of diagnostic accuracy of PSA for the detection of PCa in 14,489 symptomatic patients and a control group of 9459 men (normal DRE and PSA <4 ng/mL for 7 years), pooled data found the sensitivity of PSA to be 0.93, with a specificity of 0.20, for symptomatic patients, confirming its known high sensitivity but very poor specificity [18,19]. This evidence concerns the gene KLK3 and posterior cortical atrophy.