In another study focusing on non-DRE urine specimens, collected from patients undergoing diagnostic biopsy, a two-gene panel, consisting of PCGEM1 and PCA3, was used to differentiate high-grade cancer (Gleason score 7–10) from low-grade cancer (Gleason score 6) in a patient cohort with about 30% of African American men. The gene discussed is PCGEM1; the disease is cancer.