A comparison of tSNE analysis between normal tissues and adenoma tissue in the same I-HCA patient showed 14 cell populations; these were common in CD68high or MARCO+ macrophages (clusters #4 and #10), PECAM1+ vascular endothelial cells (cluster #9), CD8A+ T cells (cluster#5 and #6), and MYC+ proliferating cells (cluster #13) (Figure 4a,b). This evidence concerns the gene PECAM1 and adenoma.