CD8A and neoplasm: Interferon gamma (IFNγ) released from CD8+ T cells downregulates the expression of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc-, impairs the uptake of cystine by tumour cells and, as a consequence, promotes tumor cell lipid peroxidation and ferroptosis [50].