Hepcidin levels are also regulated by inflammatory cytokines, such as IL-6; IL-6 regulates the expression of hepcidin via the JAK-STAT3 pathway, which is hyperactivated in myeloproliferative neoplasms (MPNs) [28,37] and contributes to the increased hepcidin levels detected in primary MF patients [38]. Here, IL6 is linked to myeloproliferative neoplasm.