CD8A and neoplasm: Not only too high but also too low oxidative stress may prove critically detrimental in cancer: cyclic adenosine monophosphate (cAMP) activators by inducing oxidative stress impaired glioma-derived endothelial cell differentiation in vivo, normalized the tumor vessels, and altered the tumor immune profile, especially increasing the influx and function of CD8+ effector T-cells [139].