Lastly, OGG1 is a mediator of pulmonary fibrosis sparked by bleomycin; the underlying mechanism is alveolar epithelial–mesenchymal transition (EMT) and can be inhibited by small-molecule OGG1 inhibitor TH5487 or enhanced by OGG1 overexpression [141,142]. This evidence concerns the gene OGG1 and pulmonary fibrosis.