As both the TP53 and RB pathways are impaired by HPV-E6 and HPV-E7 oncoproteins, respectively, genomic alterations of TP53, RB, and CDKN2A/2B are informative for speculating HPV-independent cervical cancers, especially in gastric-type mucinous adenocarcinomas [36,37]. The gene discussed is RB1; the disease is cervical carcinoma.