Moreover, SNP rs27770 located in the 3′UTR of PLK1, which has a higher G allele frequency in the Asian population, may render PLK1 mRNA unstable by altering its second structure and hsa-miR-100-5p binding capability, resulting in a remarkably negative effect of low hsa-miR-100-5p expression on HCC prognosis in the Asian population. This evidence concerns the gene PLK1 and hepatocellular carcinoma.