Our analysis of unpaired samples revealed that mRNA expression of L3MBTL3 was significantly higher in multiple types of cancer tissues, such as cholangiocellular cancer (CHOL), colon cancer (COAD), esophageal cancer (ESCA), head and neck squamous cell cancer (HNSC), lung cancer (LUAD and LUSC), prostate cancer (PRAD), and GC (STAD). Here, L3MBTL3 is linked to colonic neoplasm.