L3MBTL3 and neoplasm: Second, we need to carry out further in vitro and in vivo experimental research on cell lines and animal models to comprehensively validate the biological functions of L3MBTL3 and the fundamental modulatory mechanisms in GC onset and advancement and to also reveal how L3MBTL3 is involved in the regulation of the tumor immune microenvironment and immune infiltration of GC.