Notably, L3MBTL3 expression was most strongly linked to macrophage infiltration (r = 0.402, p < 0.001), which is a key constituent of the tumor microenvironment (TME) and plays a role in regulating the process of angiogenesis, the proliferation of malignant cells, metastasis, extracellular matrix remodeling, and immunosuppression, along with checkpoint blockade immunotherapy and resistance to chemotherapeutic agents (Figure 5A–F) [22]. This evidence concerns the gene L3MBTL3 and neoplasm.