In a next step, we performed multivariate statistical testing using the Cox proportional hazard regression method to delineate the independence of those prognostic factors that significantly correlated with overall survival in univariate log-rank testing (see Table 2): N stage (N+ vs. N0), M stage (M1 vs. M0), UICC stage (1 + 2 vs. 3 + 4), response to therapy according to RECIST1.1 (CR vs. non-CR), tumor recurrence (yes vs. no), SEC62 expression (positive vs. negative), and chronic tobacco exposure (group 2 + 4 vs. group 1 + 3). The gene discussed is SEC62; the disease is neoplasm.