TMeF was significantly associated with primary tumor size across a variety of cancer types and subtypes, including colorectal cancer (Figure S4), non-small cell lung cancer (NSCLC) [33] (Figure S5), hormone receptor positive and triple negative breast cancer (TNBC) (Figure S6), and Gleason 4 + 3 and above prostate cancer (Figure S7). The gene discussed is NR4A1; the disease is colorectal cancer.