PDCD10 and urinary bladder cancer: Both miRs were dysregulated in bladder cancer, leading to the upregulation of CCM3, which promotes proliferation of bladder cancer cells in vitro [103] CCM3 was further reported to have clinical significance [45,103], similar to STRN4, which was found to have elevated expression in bladder cancer tissue compared to adjacent normal tissue and was significantly associated with several clinicopathological factors of patients [102].