However, the results obtained in our cohort of people living with HIV (PLWH), which demonstrate a progressive increase in CD4+ T cell count at the time of tumor diagnosis, a progressively higher nadir CD4+ T cell number, and a greater number of individuals treated with effective antiretroviral therapy, may suggest that, especially in the last decade of the study, factors related to immune aging or coinfections are more implicated in NADC development than in the severity of HIV disease itself. This evidence concerns the gene CD4 and coinfection.