Similarly, the presence of an AIDS diagnosis, a CD4+ T cell count below 200 cells per μL after 6 months on antiretroviral therapy (ART), a low nadir CD4+ T cell count, and prolonged periods of low CD4+ T cell count have been associated with elevated standardized incidence ratios (SIRs) for some non-AIDS-defining cancers in population-based studies [26]. The gene discussed is CD4; the disease is AIDS.