By inhibiting the last enzyme involved in glycolysis, pyruvate kinase (PMK-2), and consequently activating caspase-8 and caspase-9, ultimately leading to the release of gasdermin E (GSDME), PDT can induce pyroptosis of esophageal squamous cell carcinoma cells [66]. This evidence concerns the gene GSDME and esophageal squamous cell carcinoma.