VCAN and colorectal carcinoma: Using a similar approach, Liu et al. identified 311 proteins that were dysregulated in CRLM, including fibronectin 1 (FN1), tissue inhibitor of metalloproteinases 1 (TIMP1), Versican (VCAN), periostin (POSTN) and thrombospondin-1 (THBS1), which have been identified as the five most critical proteins that promote CRC metastasis [100].