HMGB4 and colorectal carcinoma: Chen et al. found that low expression of METTL4 (m6A writer) in CRC reduces m6A modification of the SRY-related high-mobility-group Box 4 (SOX4) gene, which prevents YTHDF2 (m6A reader) from being recognized and degraded by YTHDF2, while increased expression of SOX4 can promote CRC metastasis [91].