PML and leukemia: For example, promyelocytic leukemia protein (PML)-retinoic acid receptor α (RARα) is a driver of leukemia, and the transcription factor yin yang 1 (YY1), whose expression is upregulated in most tumors, can regulate the pentose phosphate pathway by modulating the activity of G6PD (6-phosphogluconate dehydrogenase) and inducing proliferation and metastasis of tumor cells [120,121].