ATP6L is needed for the activation of the Wnt/β-catenin signaling pathway, and it is also responsible for regulating the acidic tumor microenvironment, which could induce cancer cells to secrete proangiogenesis factors, such as interleukin-8 and vascular endothelial growth factor and is therefore beneficial to tumor angiogenesis and growth. This evidence concerns the gene CXCL8 and neoplasm.