MIR17HG and neoplasm: Interestingly, the MIR17HG/miR-138-5p/hexokinase (HK1/2) pathway enhances glycolysis, and increased lactate (a metabolite of glycolysis) that activates the p38/ELK1 pathway; this promotes the expression of MIR17HG and, forms a positive feedback loop for promoting tumor invasion and metastasis.