A recent study demonstrated that extensive expression of GNB4, one of the essential elements of heterotrimeric G proteins, induced by H. pylori infection prompted the invasion of GC by stimulating the YAP1 expression and its target genes, CYR61 and CTGF, indicating that GNB4 prompted the Hippo-YAP1 pathway in GC cells [102]. The gene discussed is CCN2; the disease is gastric cancer.