Mechanically, CCT5 binds to E-cadherin and disrupts the E-cadherin/β-catenin complex, thereby facilitating the nuclear transfer of β-catenin and enhancing Wnt/β-catenin signaling activity and EMT, implying a significant possibility of CCT5 as a biomarker for GC detection [54]. This evidence concerns the gene CDH1 and gastric cancer.