F-box and WD repeat domain-containing 5 (FBXW5), the E3 ubiquitin ligase, downregulated the activity of the Hippo signaling pathway by promoting large tumor suppressor kinases 1 ubiquitination, and degradation, leading to indirect YAP activation and thereby increased invasion, EMT, and metastasis of GC cells [103]. The gene discussed is YAP1; the disease is gastric cancer.