CRS is triggered by inflammatory cytokines and chemokines released by CAR-T-cells, such as interferon (IFN)γ, tumor necrosis factor (TNF)α, granulocyte macrophage colony stimulating factor (GM-CSF), and interleukins (IL)-2, IL-8, and IL-10 [98,99]. This evidence concerns the gene TNF and congenital rubella syndrome.