Another study demonstrated the enrichment of ovarian cancer tissue proteins in exosomes, including the epithelial cell surface antigen (EpCAM), epidermal growth factor receptor (EGFR), fatty acid synthase (FASN), proliferation cell nuclear antigen (PCNA), apolipoprotein E (APOE), tubulin beta-3 chain (TUBB3), claudin 3 (CLDN3), L1 cell adhesion molecule (L1CAM), and Erb-B2 Receptor Tyrosine Kinase 2 (ERBB2), which could serve as potential diagnostic markers and therapeutic targets for ovarian cancer. This evidence concerns the gene APOE and ovarian cancer.