Moreover, a report showed that when an oncolytic virus secreted IL-12p70, in addition to a PD-L1-blocking antibody combined with CAR-T-cell therapy in head and neck squamous cell carcinoma (HNSCC) xenograft models, it showed reduced growth primary and metastasized tumors compared to individual monotherapy [125]. This evidence concerns the gene CD274 and head and neck squamous cell carcinoma.