Flow cytometric and Western blot analyses showed that AAP-H impaired the cell cycle of DU-145 cells by blocking the progression of tumor cells from the S to the G2/M phase and was responsible for the dose-dependent down-regulation of p-AKT (Ser473), p-PI3K (p85) and p-mTOR (Ser2448), without altering the levels of total AKT and total PI3K. Here, AKT1 is linked to neoplasm.