The PI3K-AKT-mTOR pathway is one of the most well-known signal transduction pathways in regulating and facilitating the development of multiple human malignancies, such as breast, HCC, brain, lung, head and neck, prostate, and gastric cancers [110,111,112,113,114,115,116,117]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.