Proteins including carnitine palmitoyl transferase 2 (CPT2, involved in fatty acid transport), coatomer protein complex subunit alpha (COPA, associated with vesicle secretion), and mitogen- and stress-activated protein kinases 1 and 2 (MSK1/2, protein kinases), all of which are overexpressed in tumor cells, contribute to the regulation of prostate cancer (PCa) cell proliferation. This evidence concerns the gene COPA and prostate cancer.