In most cases, EGFR amplification is associated with a second EGFR alteration, such as EGFR::SEPT14 intergenic fusion, which is found in 4–8% of glioblastomas [30]; intragenic fusion EGFRvIII, which is found in 20–30% of glioblastomas [31,32,33]; and point mutations in the extracellular region of EGFR, which is found in 24% of glioblastomas [16]. This evidence concerns the gene EGFR and glioblastoma.