Pareja et al. studied the genetic profile of phyllodes tumors with or without a fibroadenoma-like area and found that MED12 mutation at exon 2 was significantly more frequent in tumors with fibroadenoma-like areas; however, in tumors without fibroadenoma-like areas, the enrichment of cancer genes, especially EGFR mutation and amplification, was more frequently identified. This evidence concerns the gene MED12 and cancer.