In the univariate analysis, age (p = 0.0107), hemoglobin (Hb, p < 0.0001), C-reactive protein (p < 0.0001), prothrombin time (p < 0.0001), platelet count (p = 0.0002), estimated glomerular filtration rate (p < 0.0001), presence of HCC (p = 0.0072), and ALBI score (p < 0.0001) were significant factors related to PNI < 40 (Table 2). The gene discussed is F2; the disease is hepatocellular carcinoma.