The expression levels of 4EBP1, p-4EBP1, and S6K1 were found to be significantly higher in vascular anomalies compared to normal lymphatic vessels, indicating the involvement of the mTOR pathway in lymphangiogenesis in patients with lymphatic anomalies and angiogenesis in other vascular malformations. This evidence concerns the gene EIF4EBP1 and vascular malformation.