Lymphatic malformations (LMs) are associated with mutations of the PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic alpha subunit) gene, while Kaposiform Hemangioendothelioma (KHE) is associated with the GNA14 [2] (G protein alpha subunit 14) mutation [1,3,4]. Here, PIK3CA is linked to kaposiform hemangioendothelioma.